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VWF/FVIII complex and the management of patient with inhibitors: from laboratory to clinical practice.
We and others have previously shown that inhibitor containing plasma from patients with congenital haemophilia A sometimes reacts less with von Willebrand factor (VWF) containing concentrates compared with highly purified plasma-derived or recombinant factor VIII (FVIII) concentrates. To further substantiate the haemostatic role of a variation in inhibitor reactivity with different FVIII concentra
Fathers' sense of security during the first postnatal week-A qualitative interview study in Sweden.
BACKGROUND: father's sense of security in the early postnatal period is important for the whole family. An instrument, which measures Parents' Postnatal Sense of Security (the PPSS instrument), is under development. OBJECTIVE: to explore and describe factors, which influence fathers' sense of security during the first postnatal week. METHODS: an explorative design with a qualitative approach was u
Transition in young people with myelomeningocele.
Two new species of Caloplaca from Tadjikistan, Central Asia
Two new species of Caloplaca are described, C. pseudocitrina (in the C. citrina group), which is characterized by rather long spores with a thin septum, and a squamulose thallus and C. akbarica (C. saxicola-group) characterized by rather thick, brightly yellowish pruinose apothecia and a paraplectenchymatous proper exciple. The characters of the new species and their closely allied taxa are compar
Second-harmonic generation of 405-nm light using periodically poled ${KT}i{OPO}_4$ pumped by external-cavity laser diode with double grating feedback
A frequency-doubled laser diode system for generation of blue-UV light is described. The system is based on an external-cavity high-power laser diode with double feedback from the zeroth and the first orders of a diffraction grating. Light at 405 nm is generated in a single-pass configuration using periodically poled KTiOPO4. We show that the double grating feedback improves the second harmonic co
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.
Recombinant lentiviral vectors (rLV) are powerful tools for gene transfer to the central nervous system (CNS) and hold great potential as a therapeutic gene therapy strategy for neurological disorders. Recent data indicate that rLVs are suitable for functional studies in the CNS by over expression or knock down of specific proteins. Based on a variety of lentiviruses species, different vector syst
Atmospheric mercury sources in the Mt. Amiata area, Italy
Mt. Amiata, located in southern Tuscany (Italy), is part of the geologic anomaly of the Mediterranean basin, which contains about 65% of the world's cinnabar (HgS) deposits. Atmospheric mercury emissions from the main sources (geothermal power plants, abandoned mine structures and spoil banks of roasted cinnabar ore) were determined by flux chamber and by LIDAR remote sensing. Mercury emissions fr
Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.
We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analy
Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
INTRODUCTION: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. MATERIAL AND METHODS: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphom
Contribution of pre-synaptic mechanisms to l-DOPA-induced dyskinesia.
Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic l-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key
The grade in physical education in adolescence as predictor for musculoskeletal pain diagnoses three decades later.
We hypothesized that a low grade in physical education (PE) is associated with an increased risk of future musculoskeletal conditions, especially chronic pain. Using a historical cohort study design, we identified all students (mean age 16.0years), who in 1974-1976 graduated from compulsory school in a Swedish municipality and retrieved their PE grades. We ensured that persons were still alive and
No brain structure abnormalities in boys with Tourette's syndrome: A voxel-based morphometry study
Estimates in Möbius invariant spaces of analytic functions.
We consider a class of spaces of analytic functions on the unit disc which are Möbius invariant and whose topology is essentially determined by a conformal invariant seminorm. Standard examples of such spaces are the Bloch space. BMOA, the Dirichlet spaces and their recent generalizations ${Cal Q}_K$, which make the object of our interest. We prove a general inequality for the seminorms of dilated
Planning Order Releases for an Assembly System with Random Operation Times
A multi-stage assembly network is considered. A number of end items should be delivered at a certain time. Otherwise a delay cost is incurred. End items and components that are delivered before they are needed will cause holding costs. All operation times are independent stochastic variables. The objective is to choose starting times for different operations in order to minimize the total expected
Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.
Purpose: To assess performance of a biomarker-based score that predicts the five-year risk of diabetes (Diabetes Risk Score, DRS) in an independent cohort that included 15-year follow-up. Method: DRS was developed on the Inter99 cohort, and validated on the Botnia cohort. Performance was benchmarked against other risk-assessment tools comparing calibration, time to event analysis, and net reclassi
Environmental sustainability criteria in the coffee sector – Lessons that can be learnt
In the article, the issue of environmental sustainability criteria in the coffee sector is researched. Such important aspects in this topic are highlighted and discussed as reasons for the emergence of sustainability criteria for coffee and factors that make the production of coffee sustainable. Two widely used sustainability standards for coffee, the Fair Trade Coffee sustainability standard and
Practicum-Lund Clinical Skills Center.
Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution.
The efficacy of concentrates of fibrinogen and factor XIII in hypothermia and haemodilution has not yet been completely investigated. Clauss fibrinogen measurement may overestimate fibrinogen concentrations during in vitro haemodilution with hydroxyethyl starch (HES).
Are activity limitations associated with lower urinary tract symptoms in stroke patients? A cross-sectional, clinical survey.
Objective . To assess self-reported activity limitations in a clinical sample of stroke patients and to identify their association with prevalence, severity and impact on daily life of lower urinary tract symptoms (LUTS). Material and methods . A cross-sectional, clinical survey was initiated whereby stroke patients were invited to complete four activity limitations measurements: Barthel Index, mo