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The cAMP-elevating pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin release in pancreatic B-cells. Here, we have investigated its potentiating action in rat insulinoma INS-1 cells. In intact cells, PACAP-27 (100 nM) stimulated glucose-induced insulin secretion by >60%. Using the patch-clamp technique with single-cell exocytosis monitored as increases in cell capacitanc

HIV-1 Nef has previously been shown to bind to Src homology-3 (SH3) domains of a subset of Src family tyrosine kinases. In addition, Nef has been reported to coprecipitate with a serine/threonine kinase activity termed NAK (for Nef-associated kinase). The identity of NAK remains uncertain, but it has been suggested to represent a novel member of the p21-activated kinase (PAK) family. We report her

Presents a method to use linear analysis to capture the frequency coupling of nonlinear and time-varying components. System stability is analyzed by connecting the harmonic transfer functions of the different component models. This facilitates an object-oriented approach to modeling, which supports reuse of models. An analysis of the complete railway system is, of course, difficult. Several locomo

Popular Abstract in Swedish Käkförsedda havsborstmaskar (polychaeter) var artrika och vanliga i de tidigpaleozoiska haven. Maskarnas käkar, benämda scolecodonter i den vetenskapliga litteraturen, är mycket vanliga mikrofossil i sedimentära bergarter, främst kalkstenar av denna ålder. Mycket pekar därför på att de ofta utgjorde en väsentlig del av bottenfaunan. Trots mångfalden av scolecodonter harJawed polychaete annelid worms were abundant and diverse in the early Palaeozoic seas and their jaws (scolecodonts) are common microfossils in sedimentary rocks of that age. Despite their abundance, relatively little work has been focused on these fossils. One reason for this is that their taxonomy has been, and to some extent still is, in a state of disorder, mainly because of a parataxonomic tre

In this report, numerical analyses of very narrow journal bearings are presented. The pressure distribution was determined for a number of different width-diameter ratios and eccentricities. For each combination, a number of relevant dimensionless design quantities were computed. The next step was to obtain curve-fitted functions for the variation in each design quantity. The functions are intende

Historical analysis of missiological issues arising from the World Missionary Conference, Edinburgh 1910, in comparison with missiological priorities in the international planning of the centenary conference, Edinburgh 2010

Abstract in French La mutilation génitale féminine (MGF) ou bien le terme neutre de plus de valeur, l'excision génitale féminine (EGF) est pratiquée un peu partout au Soudan, où environ 90% des femmes subissent le type le plus coûteux de l'infibulation, l'EGF. Une nouvelle approche pour combattre l'EGF au Soudan consiste à reconnaître l'ancienne forme cachée de l'EGF, la reinfibulation après l'accFemale Genital Mutilation (FGM) or the more value neutral term, Female Genital Cutting (FGC) is widely practised in northern Sudan, where around 90% of women undergo the most extensive form of FGC, infibulation. One new approach to combating FGC in Sudan is to acknowledge the previously hidden form of FGC, reinfibulation (RI) after delivery, when the woman is sewn back so much as to mimic virginit

En trygg föräldrarelation, präglad av värme och rimliga gränser, är en viktig förutsättning för barns hälsa och välfärd och för att de senare i livet ska kunna samspela förtroendefullt med omgivningen. Inom hälso- och sjukvården finns idag en omfattande verksamhet, exempelvis öppna föräldragrupper, vars syfte är att ge stöd i föräldraskapet. En aktuell rapport från Folkhälsoinstitutet visar att en

It is shown that in water of finite depth, there are no periodic traveling waves with the property that the pressure in the underlying fluid flow is constant along streamlines. In the case of infinite depth, there is only one such solution, which is due to Gerstner.

In order to be able to apply performance design procedures with regard to material flammability in building design, a comprehensive and coherent philosophy on material reaction-to-fire must be developed. This paper gives a general discussion on performance-based design and performance-based test methods for material flammability. A number of end-use scenarios and critical conditions are discussed.

We have previously shown that part of the heparin-binding domain of the vascular endothelial growth factor (VEGF), designated HBDt, localizes very selectively to surfaces of the endothelial cells of U blood vessels. Here, we have coupled the HBDt to the extracellular domain of tissue factor (TFt), to locally initiate the thrombogenic cascade. In tumor-bearing mice, infusion of this HBDt.TFt result

Food-hoarding birds use memory to relocate caches, and species that store thousands of scattered food items must have an extraordinary memory capacity to be able to relocate them. Because the hippocampus is important in the functioning of spatial memory, it is logical to assume that the amount of food stored should correlate with hippocampal volume. Previously, food-hoarding capacity has been used

The energy loss of projectiles with Z(1) in the range 3-26 has been experimentally measured in the 0.1-0.7 MeV per nucleon energy range in the same Si stopping foil of 105.5 mug cm(-2) thickness using a time of flight-energy (ToF-E) elastic recoil detection analysis (ERDA) setup. A detailed study of the experimental uncertainties for ToF-E and ToF-ToF-E configuration has been made. For ERDA config

When conducting laser based diagnostics in combustion environments it is often desirable to obtain temporally resolved information. This can be due to several factors such as combustion taking place in a turbulent flow field, flame propagation from a spark plug in an initially quiescent combustible mixture, or rapid, multi-point fuel consumption in a homogeneous charge as a result of compression i

The aim of this study was to evaluate the effects of one year of systematic clinical supervision, and supervised individually planned care on the mood and general behavior of patients with dementia in relation to their cognitive function and level of confusion. The intervention was carried out in a ward devoted to the care of patients with severe dementia (EW), with a similar ward (CW) where no ch