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Identification of a novel and myeloid specific role of the leukemia-associated fusion protein DEK-NUP214 leading to increased protein synthesis.

The t(6;9)(p22;q34) chromosomal translocation is found in a subset of patients with acute myeloid leukemia (AML). The translocation results in a fusion between the nuclear phosphoprotein DEK and the nucleoporin NUP214 (previously CAN). The mechanism by which the fusion protein DEK-NUP214 contributes to leukemia development has not been identified, and disruptions of normal cellular functions by DE

Reliability, validity and responsiveness of a new leisure index: The Patient-Specific Leisure Scale (PSLS).

Objectives: To investigate the reliability, validity and responsiveness of a new Patient-Specific Leisure Scale (PSLS), constructed to identify goals and outcomes for individual patients with rheumatoid arthritis (RA).Methods: Forty-nine patients with RA were used to evaluate test-retest reliability, and 100 consecutive RA patients were used for construct validity. Twenty-five RA patients, commenc

Molecular pathogenesis of infections caused by Moraxella catarrhalis in children.

Moraxella catarrhalis (M. catarrhalis) is a human-restricted commensal of the normal bacterial flora in the upper respiratory tract of children, and - during the previous two decades - has been recognised as a true human pathogen. M. catarrhalis is the third most common pathogen causing acute otitis media in children, which is the most common reason to visit a paediatrician during childhood. Acute

A note on tailbiting codes and their feedback encoders

Tailbiting codes encoded by feedback convolutional encoders are studied. A condition for when tailbiting will work is given and it Is described how the encoder starting state can be obtained for feedback encoders in both controller and observer canonical forms. Finally, results from a search for systematic feedback encoders that encode tailbiting codes with good decoding bit error probabilities ar

Intuition and ex-post facto reasoning in moral judgment: Some experimental findings

Psychological theories have traditionally assumed that moral judgment is caused by a reasoning process. This idea was challenged in two experiments. In the first participants were asked to make judgments in tasks set up to produce a conflict between intuition and reason. In the second, participants made judgments of morally questionable actions that were described either in a vividly disgusting wa

Error Bounds for Balanced Truncation of Linear Time-Varying Systems

In this paper error bounds for truncated balanced linear time-varying systems in discrete time are obtained. The analysis is based on direct calculations with the time-varying observability and controllability Lyapunov inequalities. The obtained bounds in the induced l-script -norm generalize well-known error-bound formulas for time-invariant systems. The case of time-varying state-space dimension

Ultrafast light-induced charge pair formation dynamics in poly[3-(2 '-methoxy-5 ' octylphenyl)thiophene]

Charge pair photogeneration was investigated by ultrafast absorption spectroscopy for different excitation photon energies in poly[3-(2(')-methoxy-5(')octylphenyl)thiophene] (POMeOPT) film with and without an external electric field. Electric field-assisted charge pair photogeneration in POMeOPT occurs from vibrationally relaxed singlet excitons during their entire lifetime and charge pair formati

No diurnal variation in rate or carbon isotope composition of soil respiration in a boreal forest

Characterization of soil respiration rates and δ13C values of soil-respired CO2 are often based on measurements at a particular time of day. A study by Gower et al. (2001) in a boreal forest demonstrated diurnal patterns of soil CO2 flux using transparent measurement chambers that included the understory vegetation. It is unclear whether these diurnal patterns were solely the result of photosynthe

Older people's views of prioritisation and resource allocation in health care

Popular Abstract in Swedish Prioriteringar av olika slag har alltid genomförts inom hälso- och sjukvård, vilket har inneburit att vissa verksamheter och patienter har prioriterats och andra har valts bort. Tidigare studier som har varit fokuserade på allmänhetens syn på vem eller vilka som ska prioriteras, har framförallt varit riktade till yngre och medelålders personer. I dessa studier framkommeThe aim of this thesis was to investigate older people's views and experience of prioritisation and resource allocation in health care, which is important because older people are the group that use public health care and service most. The aim was also to investigate differences in the view of prioritisation and resource allocation in relation to age, gender, housing, health-related quality of lif

Algorithmic Methods in Combinatorial Algebra

Popular Abstract in Swedish Avhandlingen, som består av tre delar, handlar om olika metoder för att undersöka algebraiska begrepp med hjälp av datorberäkningar. I första delen visar vi att en viss Liealgebra inte, till skillnad från många andra Liealgebror av liknande typ, kan brytas ned i vinkelräta komponenter av en speciellt enkel typ. Andra delen handlar om vilka polynom som kan bildas genomThis thesis consists of a collection of articles all using and/or developing algorithmic methods for the investigation of different algebraic structures. Part A concerns orthogonal decompositions of simple Lie algebras. The main result of this part is that the symplectic Lie algebra C3 has no orthogonal decomposition of so called monomial type. This was achieved by developing an algorithm for fin

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Churches and elite in Trøndelag: A review of Jan Brendalsmos dissertation "Kirkebygg og kirkebyggere. Bygherrer i Trøndelag ca. 1000-1600" (Churuch buildings and church builders in Trøndelag ca. 1000-1600), Oslo 2006.

Determinants of lung function and airway hyperresponsiveness in asthmatic children

Background: Asthma patients exhibit an increased rate of loss of lung function. Determinants to such decline are largely unknown and the modifying effect of steroid therapy is disputed. This cross-sectional study aimed to elucidate factors contributing to such decline and the possible modifying effect of steroid treatment. Methods: We analyzed determinants of lung function and airway hyperresponsi

Fluxes of ammonia in the marine coastal boundary layer.

Concentrations of ammonia in air and ammonium in surface water were measured from a platform in the Southern North Sea close to the Dutch coast. Fluxes were derived from the measurements applying Monin–Obukhov similarity theory and exchange velocities calculated. The fluxes and air concentrations of ammonia were compared to results obtained from the Lagrangian transport-chemistry model ACDEP with

Unintegrated parton density functions

An overview on activities to determine unintegrated parton density functions is given and the concept and need for unintegrated PDFs is discussed. It is also argued that it is important to reformulate perturbative QCD results in terms of fully unintegrated parton densities, differential in all components of the parton momentum. Also the need for non-linear BFKL evolution is discussed and results u

Flavour independent searchesfor hadronically decaying neutral Higgs bosons

This paper describes flavour independent searches for hadronically decaying neutral Higgs bosons in the data collected by the DELPHI experiment at LEP, at centre-of-mass energies between 189 and 209 GeV. The collected data-set corresponds to an integrated luminosity of around 610 pb(-1). The e(+)e(-) -> hA and e(+)e(-) -> hZand processes are considered, with direct Higgs boson decays into hadrons.