Aims/hypothesis: An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prevalence. However, MTNR1B missense variants have shown conflicting results on type 2 diabetes. Thus, we aimed to gain further insights into the impact of MTNR1B coding variants on type 2 diabe

Due to higher demands on the electrical systems in the aviation industry, the generation and distribution of electrical power, in aircrafts, needs to be researched and developed further. Key requirements include increased power capacity to meet future demands, a transition from AC to DC supply and an increased voltage level. For power generation, a generator is coupled to the jet turbine which mus

This thesis investigated the potential of using reactive power compensation to solve overvoltage issues caused by high amounts of distributed generation, such as rooftop photovoltaic (PV) systems, in the low voltage grid. High voltages are caused by increasing distributed generation as the Swedish power grid shifts from centralised to decentralised power production. The aim was to manage overvol

The international business literature predominantly explains internationalization through the lens of developed countries and well-established firms, offering limited insights into how emerging market startups expand globally. To address this gap, this study investigates the internationalization processes of technology startups from Kazakhstan. Employing a qualitative research design, semi-structu

This thesis aims to illustrate how Environmental, Social, and Governance (ESG) scores influence both shareholder perception of firm performance and actual firm performance within Emerging Market Multinational Enterprises (EMNEs). As sustainability becomes a priority in global markets, EMNEs are often subject to increased investor scrutiny due to distinctive challenges and standards present within

Detecting and recognizing when there is a deviation in process behavior is a crucial aspect of industrial automation. This study investigates one such deviation, a volume discrepancy accidentally introduced during the commissioning of a Tetra Pak Standardization Unit (TPSU). The analysis aims to develop theory for a future implementation with the purpose of detecting this deviation by evaluating p

This thesis investigates how the integration of post-combustion carbon capture (PCC) systems would affect combined heat and power (CHP) plant performance, using DWSIM, an open- source process simulation tool. A case study on a CHP plant in southern Sweden was conducted, with models simulated for both baseline and CCS-integrated operation. DWSIM proved accurate within a relative error of under 3 %

Syfte & mål: Syftet med studien är att förklara vikten med projektering för demontering så att byggsektorn kan nå de uppsatta klimatmålen. Rapporten ska ge en övergripande kunskap kring ämnet och även beskriva vilka påföljder implementering av PfD leder till samt hur det kan förändra och påverka byggsektorn till det bättre. Problemställning: Klimatavtrycket är idag en central del inom byggbrPurpose & goal: The purpose of the study is to explain the importance of design for disassembly so that the construction sector can achieve its set climate goals. The report aims to provide an overall understanding of the topic and also describe the consequences of implementing Design for Disassembly (DfD), as well as how it can transform and positively impact the construction sector. Proble

Billions of animals undertake migratory journeys every year, with powerful consequences for ecosystem dynamics. Key behaviours that enable successful migration are often guided by the visual system. The amount and quality of information that animals can extract from visual scenes are directly related to structural eye size—larger eyes can house larger pupils, enhancing light-gathering capacity and

Extraordinary finds from the Store Frigård cremation cemetery on the Danish island of Bornholm suggest that the society that used the site played a key role in supra-regional contacts and in the distribution of goods and people across the Baltic Sea between the Continent and Southern Scandinavia during the Iron Age.

Purpose: The aim of this study was to evaluate bony fusion with Low Dose CT (LDCT) over time following posterior scoliosis surgery in an all screw construct in patients with AIS with special focus on whether the spinal fusion process continue to develop beyond 2 years after scoliosis surgery and to evaluate if LDCT is an adequate radiological method to assess fusion maturation. Methods: Twenty fiv

Nya molekyler blockerar vattenkanaler som främjar tumörutveckling I detta projekt upptäcktes två nya molekyler som stänger aquaporin-3, en viktig vattenkanal i våra celler. Projektet kan öppna nya vägar för cancerbehandling genom att inaktivera ett centralt stödsystem för tumörtillväxt. Aquaporiner är små, specialiserade proteiner som bildar kanaler i cellmembranen. De kontrollerar vattenflödet This thesis identified two novel inhibitors of aquaporin-3 with comparable potency to the current leading compound, DFP00173. This achievement was based on the hypothesis that new aquaporin inhibitors could be developed by building upon the chemical structure of DFP00173. Aquaporins are a class of transport proteins responsible for the transport of water through the cell membranes. Aquaporin-3 is

Purpose: To investigate the financial firm characteristics determining investment decisions alongside value creation differences across different investment types and whether private equity investors have a treatment effect on operating firm performance. Theoretical perspectives: The theoretical perspectives of this paper consist of contracting related theories applicable in the private equity env

På bostadsmarknaden har hyrköp införts som en ny form av boende. Hyrköp går ut på att köparen under en tid hyr bostaden med en option om att köpa loss bostaden vid slutet av optionen. Denna upplåtelseform har hittills varit oreglerad enligt lag, vilket kan skapa osäkerhet. I synnerhet vid hyrköpsavtal med fast egendom där avtal om framtida köp enligt praxis inte är bindande. Inom riksdagen har det

Purpose: The purpose of this thesis has been to examine if and how Swedish SMEs use post audit reviews to learn from their capital investment decisions. Methodology: This explorative study applies a qualitative research approach, using both primary and secondary data. The primary data was collected through semi structured interviews with six managers across six different Swedish SMEs, while secon