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Investigations of selectively laser-excited atoms and molecules
Imiquimod shows anti-viral actions in human bronchial epithelium - implications for COVID-19 treatment
Combining anti-viral and anti-inflammatory effects in a single drug may be beneficial in treating COVID-19. We hypothesized that the TLR7 agonist imiquimod (imq) may exert these actions in human bronchial epithelial cells (HBECs), which are targets in SARS-CoV-2 mediated lung injury. Methods: Using primary HBECs from asthmatic donors (N=18), we explored actions of imq related to airway viral resis
Diagnostic value of analysis of cystatin C and protein HC in biological fluids
Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological
Oral fluoroquinolone use and the risk of acute liver injury: a nationwide cohort study
Antibiotics are considered to be among the most frequent causes of drug-related acute liver injury (ALI). Although many ALIs have mild and reversible clinical outcomes, there is substantial risk of severe reactions leading to acute liver failure, need for liver transplant, and death. Recent studies have raised concerns of hepatotoxic potential related to the use of fluoroquinolones.MethodsThis stu
Bedömning för triagering
Konventionella metoder ledde fel i diagnos av gåtfull urinäggvita
Phenomenological investigations in hadron physics with emphasis on quark structure
Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy
The effect of human recombinant cystatin C, a cysteine proteinase inhibitor, on bone resorption in vitro was evaluated. Bone resorption was assessed by analyzing the release of 45Ca and 3H from mouse calvarial bones prelabeled in vivo by injections with 45Ca or [3H]proline, respectively. In 24 h cultures, cystatin C (50 micrograms/ml) significantly inhibited the release of 45Ca and 3H stimulated b
Optical techniques for nonintrusive studies on combustion and high-voltage systems
A Biosensing Strategy for Fast Profiling of Antibiotic Resistance
Antibiotic resistance threatens global public health. Clinical methods that simplify and accelerate resistance diagnosis are urgently needed. Here we describe a function-based antibiotic resistance detection and classification strategy to improve diagnosis. The method identifies resistance enzymes by directly measuring the thermal signal generated when an antibiotic i enzymatically degraded. A sub
Impurities in some wide-gap semiconductors
Application of laser spectroscopy to combustion and environmental probing
Microcalorimetric studies on uraemic plasma
The heat production by human plasma in healthy and uraemic subjects has been measured by direct isothermal microcalorimetry. The plasma from uraemic subjects displayed an increased heat production compared to that of normal plasma. The heat production by plasma from healthy subjects, but not by that from uraemic patients, was both proportional to the amount of thiol groups in the plasma and also t
Estrella lausannensis, a new star in the Chlamydiales order
Discovery of new intracellular pathogens by amoebal coculture and amoebal enrichment approaches.
A rapid enzyme-linked immunosorbent assay for serum amyloid A using sequence-specific antibodies
A microtitre plate based enzyme-linked immunosorbent assay for determining the concentration of serum amyloid A (SAA) is described. The method employs easily produced sequence-specific rabbit antibodies and the preferential absorption of SAA to polystyrene, which obviates the use of capture antibodies and allows an assay time of only 3.5 h, so that the diagnostic potential of the SAA level as a ra
Identification of immunogenic proteins of Waddlia chondrophila
Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia
Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. These alterations lead to gain of oncogenic functions, loss of tumor suppressor functions, or may be chromosom