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The accuracy and robustness of plasma biomarker models for amyloid PET positivity

BACKGROUND: Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or initiating Aβ-targeting treatments would be of critical value. In this study, we aimed to examine the robustness of plasma biomarkers to detect elevated Aβ pathology at different

The future distribution of wetland birds breeding in Europe validated against observed changes in distribution

Wetland bird species have been declining in population size worldwide as climate warming and land-use change affect their suitable habitats. We used species distribution models (SDMs) to predict changes in range dynamics for 64 non-passerine wetland birds breeding in Europe, including range size, position of centroid, and margins. We fitted the SDMs with data collected for the first European Breed

Metagenomic evidence of a novel family of anammox bacteria in a subsea environment

Bacteria in the order 'Candidatus Brocadiales' within the phylum Planctomycetes (Planctomycetota) have the remarkable ability to perform anaerobic ammonium oxidation (anammox). Two families of anammox bacteria with different biogeographical distributions have been reported, marine Ca. Scalinduaceae and freshwater Ca. Brocadiaceae. Here we report evidence of three new species within a novel genus a

Problemdefinitioner i samtal med klienter – ett interaktionistiskt perspektiv

Människobehandlande yrken, såsom socialt arbete, syftar till att identifiera och åtgärda problem i människors liv. Hur skapas en förståelse av vad ett problem innebär? Hur nås enighet i fall där det finns flera motstridande definitioner och förklaringar till vad som ska anses vara problematisk? Detta kapitel handlar om hur en förståelse av ett problem och lösningar på det kan skapas i ett möte melMänniskobehandlande yrken, såsom socialt arbete, syftar till att identifiera och åtgärda problem i människors liv. Hur skapas en förståelse av vad ett problem innebär? Hur nås enighet i fall där det finns flera motstridande definitioner och förklaringar till vad som ska anses vara problematisk? Detta kapitel handlar om hur en förståelse av ett problem och lösningar på det kan skapas i ett möte mel

Att mötas i den skrivande stunden – om stödjande samtal via chatt

I detta kapitel undersöker vi några av de frågor som uppstår när mötet med klienten är begränsat till de skrivna orden. Hur visar man sin närvaro när man inte ser varandra? Hur förmedlar man förståelse och stöd i en textbaserad dialog? Vi går igenom skillnader mellan stödjande samtal i det fysiska rummet och textbaserat stöd på internet. Utifrån tidigare forskning och exempel från en chatt, som erI detta kapitel undersöker vi några av de frågor som uppstår när mötet med klienten är begränsat till de skrivna orden. Hur visar man sin närvaro när man inte ser varandra? Hur förmedlar man förståelse och stöd i en textbaserad dialog? Vi går igenom skillnader mellan stödjande samtal i det fysiska rummet och textbaserat stöd på internet. Utifrån tidigare forskning och exempel från en chatt, som er

Wheat starch structure and bread quality

Starch is the most abundant component in wheat flour, but has not traditionally been regarded as responsible for differences in quality between wheat varieties. In this chapter the role of starch in the baking process is described and examples on the role of starch during mixing, fermentation, and the oven step are given. The relevance of starch for baking performance is discussed, e.g., the setti

Revealing Three-Dimensional Morphology in Nanoporous Gold Using Three-Dimensional X-Ray Fresnel Coherent Diffractive Imaging Tomography

Nanoporous metals fabricated by dealloying have a unique bi-continuous, sponge-like porous structure with ultra-high surface area. The unique properties of these materials, especially nanoporous gold, have numerous potential applications in sensors and actuators and in energy-related applications such as catalytic materials, super-capacitors, and battery supports. The degree of porosity and size o

Plants effective against insomnia and sleep apnea

Insomnia and sleep apnea represent the most prevalent sleep disorders worldwide. Incidences are discouraging, with perhaps less attention in some parts, and the complexity in the pathophysiologies of the two diseases pose a major challenge to clinicians and researchers. Mainstream therapeutic regimens are afflicted by adverse side effects, laborious, demanding enormous amounts of money, and are in

Lead

Inorganic lead is the most extensively studied environmental toxin. Today's humans have in the order of 100 times higher lead exposure, compared to prehistoric humans, mainly from food. The exposure was even higher during the 20th century, mainly due to lead addition to gasoline. Today, high exposures occur in many occupations, but also through, for example, contaminated drinking water, traditiona

Friction in Transitional Justice Processes : The Colombian Judicial System and the ICC

With the aim of understanding how the International Criminal Court (ICC) affects peace processes, this article examines the Colombian peace and justice processes through the lens of friction. It investigates frictional encounters between the Colombian judicial system and the ICC, in order to reveal the tensions in this relationship. First, we disaggregate the concept of friction and propose three

Orientational arrest in dense suspensions of elliptical particles under oscillatory shear flows

We study the rheological response of dense suspensions of elliptical particles, with an aspect ratio equal to 3, under oscillatory shear flows and imposed pressure by numerical simulations. Like for the isotropic particles, we find that the oscillatory shear flows respect the Cox-Merz rule at large oscillatory strains but differ at low strains, with a lower viscosity than the steady shear and high

Shape-shifting and pushing against the odds : staff perceptions of the experiences of first generation students in South Africa and the UK

The principles of diversity and inclusion are valued across the higher education sector, but the ways in which these principles are translated into pedagogic practice are not always evident. Students who are first in their family to attend university continue to report barriers to full participation in university life. They are more likely to leave their studies early, and to achieve lower grades

Myths and legends : Changing assessment procedures and practices

Leading change in relation to assessment is a significant challenge; almost everyone in the university is a stakeholder and they may have strong and varied views about how assessment should be managed. A baseline review of assessment practices at a large, diverse, and complex university showed that the prevailing culture around assessment was equivocal and that people were fearful of large-scale c

The wicked problem of healthcare student attrition

The early withdrawal of students from healthcare education programmes, particularly nursing, is an international concern and, despite considerable investment, retention rates have remained stagnant. Here, a regional study of healthcare student retention is used as an example to frame the challenge of student attrition using a concept from policy development, wicked problem theory. This approach al

Global citizenship education-Assessing the unassessable?

This chapter explores the role of assessment in global citizenship education (GCE). We will consider what can be assessed, and how teachers can design and manage appropriate assignment tasks in relation to normative assessment practices. The ways in which assessment might inform curriculum, behaviours, and engagement with GCE are considered in relation to institutional practices. The role of the a

The potential of student narratives to enhance quality in higher education

University policies are increasingly developed with reference to students’ learning experiences, with a focus on the concept of the ‘student voice’. Yet the ‘student voice’ is difficult to define and emphasis is often placed on numerical performance indicators. A diverse student population has wide-ranging educational experiences, which may not be easily captured within the broad categories provid

Identifying needs and opportunities for academic development

This chapter examines the role and responsibilities of the individual academic developer and how these reflect the context of the engagement. It considers how different responses to the development context can be identified - not as a prescription designed to treat each individual case, but as a framework for evaluating the need and creating an environment for meeting it successfully. It will make

Supporting the development of assessment literacy of staff through institutional process change

This paper reflects on the work done at a large UK university to redesign assessment procedures in a way that was intended to contribute to an improvement in assessment literacy for staff. Existing practice was reviewed and showed that changes in assessment processes were needed to make the organization of assessment more consistent and more transparent across the institution and to develop staff