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Molecular stratification of bladder cancer has revealed gene signatures differentially expressed across tumor subtypes. While these signatures provide important insights into subtype biology, the transcriptional regulation that governs these signatures is not well characterized.
Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography
The objective of the study was to test whether live plants on computer workstations with and without window view had restorative effects. Guided by Stress Recovery Theory and Attention Restoration Theory a mixed randomized experiment was conducted exploring restorative effects of plants, including mediating effects of perceived fascination. Eighty-five participants carried out a 1-hr work session
To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort. Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up da
Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare, but the highest in some developing countries. Insight into its precursor lesions, pathogenesis and risk factors offers options to prevent this potentially mutilating disease. This review presents an overview of the different histologically and clinically identified precursor lesions of penile cancer
Popular Abstract in Swedish Rörelseorganens sjukdomar är ett samlingsnamn för sjukdomar i skelett, muskler, leder och senor. Rörelseorganens sjukdomar är tillsammans med psykiska sjukdomar den vanligaste orsaken till sjukskrivning i Sverige. I sjukskrivningssammanhang studeras ofta rörelseorganens sjukdomar som en grupp men i själva verket innehåller gruppen en mängd olika sjukdomar och symptom soOsteoarthritis (OA) is one of the most common causes of pain and disability in the musculoskeletal system. Even though the prevalence of OA increases rapidly with age, OA also impacts the working age population. The overall aim of this thesis was to increase the knowledge on sick leave and disability pension in OA and other musculoskeletal disorders (MSDs). Specific aims were to study patients ex
In dibromomesitylene, only the methyl group denoted Me-2 and surrounded by two bromine atoms, is a quasi free rotor. In isotopic mixtures the Me-2 tunnelling gap is almost insensitive to variations in temperature and to isotopic dilution. The Me-2 hindering potential remains the same as in the pure material with a main component cos6 theta. Because there is no coupling between the methyl groups, d
Alterations in cellular pathways related to both endocrine and vascular endothelial growth factors (VEGF) may contribute to breast cancer progression. Inhibition of the elevated levels of these pathways is associated with clinical benefits. However, molecular mechanisms by which endocrine-related pathways and VEGF signalling cooperatively promote breast cancer progression remain poorly understood.
Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis,
Introduction: Fenestrated aortic stent-grafts are increasingly being used to treat patients with juxtarenal abdominal aortic aneurysms (AM). Sizing of these stent-grafts is critical to ensure success and requires detailed expert assessment of aortic morphology. At present little is known about how sizing of these stent-grafts varies between observers and the necessary tolerances involved to ensure
Recent investigations of core-shell nanowires using synchrotron radiation techniques deduced the average structural parameters of heterostructure core-shell nanowires. Here, we report on first results and discuss the problems arising when measuring such complex nanostructures by using nanofocusing X-ray techniques. InAs/IAsP core-shell nanowires exhibit a certain bending, the origin of which is de
Using the findings of incident investigations to improve patient safety management is well-established and mandatory under Swedish law. This study seeks to identify the mechanisms behind successful implementation of the recommendations of incident investigations.
A combination method of frequency domain photon migration (FDPM) and gas in scattering media absorption spectroscopy (GASMAS) is used for assessment of the mean optical path length (MOPL) and the gas absorption in gas-filled porous media, respectively. Polystyrene (PS) foams, with extremely high physical porosity, are utilized as sample materials for proof-of-principle demonstration. The optical p
This work studies osteoinduction and bone conduction in polyvinyl alcohol-tetraethylorthosilicate-alginate-calcium oxide (PTAC) biocomposite cryogels along with the synergistic effect of electrical stimulation. In vitro osteoinduction of C2C12 myoblast towards osteogenic lineage is demonstrated through alkaline phosphatase assay, scanning electron microscopy and energy dispersive X-ray spectroscop
