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The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. In our study these cells exhibited molecular and functional properties resembling those of adult human astrocytes
A numerical formulation is provided for secondary ice production during fragmentation of freezing raindrops or drizzle. This is obtained by pooling laboratory observations from published studies and considering the physics of collisions. There are two modes of the scheme: fragmentation during spherical drop freezing (mode 1) and during collisions of supercooled raindrops with more massive ice (mod
Ferroan granitoid intrusions are rare in the Archaean rock record, but have played a large role in the evolution of the Proterozoic crust, particular in relation to anorthosite-mangerite-charnockite-granite suites. Here we discuss the petrogenesis of the ca. 2785–2805 Ma ferroan Ilivertalik Intrusive Complex, which has many geochemical similarities to Proterozoic iron rich granitoids. We present m
Because several studies have implicated serotonin as a regulator of bone mass, we here explore its potential association on fracture risk and falls, as on bone mineral density (BMD) and muscle strength, in humans. Serum levels of serotonin were analyzed in 950 men (aged 69 to 81 years), participating in the Gothenburg part of the population-based study MrOS Sweden. Men taking selective serotonin r
The Swedish Agency for Health Technology Assessment and Assesment of Social Services (SBU) is an independent national authority, tasked by the government with assessing methods used in health, medical and dental services and social service interventions from a broad perspective, covering medical, economic, ethical and social aspects. The language in SBU's reports are adjusted to a wide audience. S
According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS), most of the publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO
Soils in Arctic and boreal ecosystems store twice as much carbon as the atmosphere, a portion of which may be released as high-latitude soils warm. Some of the uncertainty in the timing and magnitude of the permafrost-climate feedback stems from complex interactions between ecosystem properties and soil thermal dynamics. Terrestrial ecosystems fundamentally regulate the response of permafrost to c
Background: Hyperuricemia (HU) is in the causal pathway for developing clinical gout. There are few population-based assessments of the absolute and relative risk of clinically diagnosed incident gout in subjects with HU. We aimed to explore the long-term risk of developing incident gout among asymptomatic adults with different levels of serum urate (SU). Methods: Malmö Preventive Project was a po
This paper provides empirical evidence in support of the clash-of-civilizations view on the nature of interstate conflicts in the post-Cold War era. First, we show that countries belonging to different civilizations have a higher probability of interstate conflict before and after the Cold War period, but not during the Cold War. Second, we explain the differential impact of civilizations on confl
This paper examines the role of ethnic minorities in bilateral trade between countries of the ex‐Soviet Union. We argue that both forced re‐settlement of entire ethnic groups during the Stalin era and artificially drawn borders in Central Asia led to an exogenous ethnic composition within countries. Using data collected by ethnologists on the share of ethnic groups across countries, we build an in
This paper assesses the effect of the Russo–Georgian conflict of 2008 and the Ukrainian–Russian conflict of 2014 on the well-being of minorities in Russia. Using the Russian Longitudinal Monitoring Survey (RLMS), we find that the well-being of Georgians in Russia suffered negatively from the 2008 Russo–Georgian conflict. We show that the conflict has no direct effect on the labor market outcomes o
The determinants of countries' long‐term income differences feature prominently in the literature. Spolaore and Wacziarg (The diffusion of development, Quarterly Journal of Economics, 2009, 124, 469–529) argue that cultural differences, measured by countries' genetic distance, are an important barrier to the diffusion of development from the world's technological frontier. We revisit their finding
This paper studies the Clash of Civilizations hypothesis from an economic perspective. Using data on bilateral trade and measures of culture, we evaluate how the impact of cultural differences on trade evolves over time during and after the Cold War. Evidence suggests that the negative influence of cultural differences on trade is more prominent in the post-Cold War era than during the Cold War. F
