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The transient receptor potential (TRP) melastin 8 ion channel (TRPM8) is implicated in bladder sensing but limited information on TRPM8 antagonists in bladder overactivity (BO) is available. This study characterizes a new TRPM8-selective antagonist (DFL23448) and evaluates it in cold-induced behavioral tests and on bladder function and experimental BO in vivo in rats. DFL23448 displayed IC50 value

PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented

We present a comparison of chemistry-transport models (TransCom-N2O) to examine the importance of atmospheric transport and surface fluxes on the variability of N2O mixing ratios in the troposphere. Six different models and two model variants participated in the inter-comparison and simulations were made for the period 2006 to 2009. In addition to N2O, simulations of CFC-12 and SF6 were made by a

Abstract in UndeterminedWe introduce a new method for prestack depth migration of seismic common-shot gathers.The computational procedure follows standard steps of the reverse-time migration, i.e.,downward continuation of the `source' and the `receiver' waveelds, followed by applicationof an imaging condition (e.g. zero-lag cross-correlation of these elds). In our method werst nd a sparse data rep

Iran has the highest rate of road traffic accidents (RTAs) worldwide. Iranian studies of the growing levels of RTAs are often conducted by medical doctors, who view them in light of the increase in the production and ownership of cars and the changed lifestyle of many Iranians, and discuss them in terms of pathology, morbidity and epidemiology. This paper argues that although the high levels of RT

In Parkinson's disease (PD) progressive alteration of striatal N-methyl-D-aspartate receptors (NMDARs) signaling has emerged as a considerable factor for the onset of the adverse motor effects of long-term levodopa (L-DOPA) treatment. In this regard, the NMDAR channel blocker amantadine is so far the only drug available for clinical use that attenuates L-DOPA-induced dyskinesia (LID). In this stud

Human stability control is a complex process comprising contributions from several partly independent mechanisms such as coordination, feedback and feed-forward control, and adaptation. Acute alcohol intoxication impairs these functions and is recognized as a major contributor to fall traumas. The study aimed to investigate how alcohol intoxication at .06% and .10% blood alcohol concentration (BAC

We consider the dynamics of a one-dimensional system consisting of dissimilar hardcore interacting (bouncy) random walkers. The walkers' (diffusing particles') friction constants ξ(n), where n labels different bouncy walkers, are drawn from a distribution ϱ(ξ(n)). We provide an approximate analytic solution to this recent single-file problem by combining harmonization and effective medium techniqu

The C-14 dating method is the cornerstone for inferring age estimates for natural archives covering the last 50 000 yrs. However, C-14 age calibration for the last ice age relies mostly on records that only indirectly reflect the atmospheric C-14 concentrations. In consequence, calendar age estimates are significantly more uncertain for the period of the last ice age compared to the past 14000 yrs

The genus Achrysocharoides Girault is here reported for the first time from tropical America. Included are ten species, eight newly described: A. asperulus, A. callisetosus, A. cuspidatus, A. foveatus, A. infuscus, A. mediocarinatus, A. purpureus, A. sulcatus, and two already known: A. ecuadorensis (Hansson) and A. gliricidiae (Hansson & Cave). All species are included in an identification key

Type 2 diabetes mellitus (T2DM) and HER2 are associated with cancer although the role of HER2 in T2DM is not well defined. Our aim was to investigate the association between HER2 levels and T2DM and whether that association was different in Swedish people born in Iraq or Sweden.

This paper explores the attitude-behaviour gap from an identity perspective in order to better understand why tourists act sustainably at "home" but not when "away". The majority of tourism-related CO2 emissions stems from transport. Behavioural change is a possible way to reduce those emissions. However, research indicates that instigating behavioural change within tourism is problematic, because

Neuropathological and cell culture studies suggest that tau and alpha-synuclein pathologies may promote each other. To study the relevance and functional implications of these findings in vivo, we transduced hippocampal neurons of wild-type or human A30P alpha-synuclein transgenic mice with wild-type or P301S mutated human tau using an adeno-associated virus vector. Green fluorescent protein trans

Manual software testing is a widely practiced verification and validation method that is unlikely to fade away despite the advances in test automation. In the domain of manual testing, many practitioners advocate exploratory testing (ET), i.e., creative, experience-based testing without predesigned test cases, and they claim that it is more efficient than testing with detailed test cases. This pap

This article examines how professional wrestlers, promoters and audiences perform the passion work of sports entertainment. Rather than celebrate professional wrestling as a popular phenomenon, this articles seeks to use empirical research on live wrestling events to understand the meaning of passion work in sports entertainment. In Roland Barthes’ seminal article on professional wrestling in Myth

Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety of age-dependent blood cell pathophysiologies. Mechanistic drivers of hematopoietic stem cell (HSC) aging include DNA damage accumulation and induction of tumor suppressor pathways that combine to reduce the regenerative capacity of aged HSCs. Such mechanisms do not however account for the change i

The northern terrestrial net ecosystem carbon balance (NECB) is contingent on inputs from vegetation gross primary productivity (GPP) to offset the ecosystem respiration (R-eco) of carbon dioxide (CO2) and methane (CH4) emissions, but an effective framework to monitor the regional Arctic NECB is lacking. We modified a terrestrial carbon flux (TCF) model developed for satellite remote sensing appli

This paper discusses a number of questions with regard to Sweden’s economic and political development: † How did Sweden become rich? † What explains Sweden’s high level of income equality? † What were the causes of Sweden’s problems from 1970 to 1995? † How is it possible that Sweden, since the crisis of the early 1990s, is growing faster than most EU countries despite its high taxes and generous