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Formulation development of a recombinant VAR2-antiCD3 protein for cancer immunotherapy

Varje år, varje dag, varje timme, dör någon av cancer. Cancer är den näst dödligaste sjukdomen i världen efter hjärt- och kärlsjukdomar. Dessutom drabbar sjukdomen inte bara de som dör. Många lider fysiskt och psykiskt av sin diagnos och nära och kära utsätts för stor oro för sina närstående. Den bispecifika molekylen rVAR2-aCD3 är ett nytt, lovande läkemedel mot cancer som snart kan börja prövas The use of immunotherapy for treating cancer has received a lot of attention in the recent years. The therapy is based on activating or deactivating the patient’s own immune system to help fight the disease. One way of doing this, is using bispecific molecules that can target both cancer cells and T-cells simultaneously. In 2003, a researcher found that the surface protein VAR2, expressed on mala

Designing a Tool for Improved Decision Documentation in Collaborative Projects

When working in collaborative projects with team members with different expertises, often from different companies, communicative and collaborative challenges that obstructs decision-making can arise due to team members having different objectives. In order to avoid problems and conflicts, good documentation of decision related information is required. The project was performed at Yolean AB, a com

Quantification of Fetal Volume in Magnetic Resonance Images Using Deep Learning

Background: Fetal Magnetic Resonance Imaging is an imaging technique that visualizes the fetus during pregnancy. It is used for assessing and diagnosing disease, for monitoring high risk pregnancies, and for conducting research. By segmenting three-dimensional fetal magnetic resonance (MR) images, volume estimation of intrauterine structures is possible. The quantification of fetal body volume and

The Stock market and Human development

Stock market development and its relationship with economic growth has been proven to be significant in previous research but how does it relate to human development? The Human Development Index was first released with the 1990 Human Development Report. If stock market development could impact economic growth could it also impact human development? To analyse the relationship a regression model wa

Design of a rugged intercom system with an interaction design approach

Within a technology-driven company, product usability and interaction design is usually not the main focus. This thesis applies a Human-Centered design process with the aim of creating a more usable and intuitive product. The project is made in collaboration with Axis Communications who aims to expand its portfolio by transferring two intercoms from its subsidiary 2N Telekomunikace to its own asso

Covid-19-pandemins konsekvenser på svenskt näringsliv - en Space Syntax analys

I december 2019 upptäckte smittskyddsmyndigheten i Kina ett helt nytt virus som senare skulle visa sig spridas och bryta ut till en pandemi över hela världen. Viruset har sedan dess fått namnet SARS-CoV-2 och bidrar till sjukdomen Covid-19. Viruset upptäcktes och identifierades för första gången i staden Wuhan i Hubeiprovinsen, för att sedan spridas till ett stort antal länder över hela världen. DIn December 2019, authorities in China discovered a completely new virus that since then has spread worldwide leading to a pandemic. The virus has since been named SARS-CoV-2 and contributes to infection of Covid-19. The current situation (2021-01-01) of the covid-19-pandemic has affected us all with a rate of 60 million global cases, several unfortunate deaths and a great uncertainty regarding an

Property Tax Mapping and Assessment Using GIS: Case study of Rawalpindi City

PROPERTY TAX MAPPING, ASSESMENT & MONITORING USING GIS Property tax recovery is considered one of the most challenging tasks for governments around the globe in general and in third world countries including Pakistan, India, and Sri Lanka in particular. Today, the existing real property assessment and tax collection system are under pressure to increase its efficiency. Moreover, monitoring anProperty Tax Mapping and Assessment Using GIS Property tax recovery has remained one of the challenging tasks over the years for almost every government around the world, especially in third-world countries. Today, the existing property assessment and tax collection system in Pakistan is antique and defective in many ways and is under pressure to increase its efficiency and tax revenue. Tax asse

”Må Gud välsigna dig med ilskans vrål” - En performativ analys av Sara Parkmans album Vesper

In the last ten years, there has been an ongoing cultural conflict between the nationalist political party the Sweden Democrats (Sverigedemokraterna) and a big group of active Swedish folk musicians. The conflict concerns the definition of ’folk music’ and the question if the genre is to be considered as an inherently more ‘Swedish’ form of cultural expression than other types of music. The Sweden

Bound to Benefit: Exploring How Gender Roles and Relations Shape Women’s Access to Economic Growth from Connectivity: One Case of the Road Corridor in Armenia

The study takes off from gender studies, aiming to identify and explore the relations and roles that people share in society that shape their daily lives. Road corridor investments and how they affect women are argued to be in the middle of a development dilemma where three global agendas that appear incompatible are yet promoted simultaneously. The study aims to explore how gender roles and relat

COOL IT DOWN - Tackling urban heat island effect in Singapore

This master thesis aims to propose sustainable solutions to influence the microclimate, tackle the urban heat island effect and provide a climate-sensitive design for Marina Bay in Singapore. During the site visit and research, the main challenges for Downtown Singapore were identified. The most threatening ones included increasing temperature and the heat island effect. The design principles co

Waring’s Problem and the Hardy-Littlewood circle method

In this bachelor thesis, we appply the Hardy-Littlewood circle method to Waring's problem using Vinogradov's exponential sums approach. On the last section, we focus on the consequeces of the recently proved Vinogradov's mean value theorem.

Fiscal Policy, R&D and Innovation

Innovation, made possible through Research and Development (R&D) is a major driving force of economic growth. Due to its quasi-public good nature investments in R&D is usually below the social optimum. Governments use different policy instruments to correct this market failure. In this paper, the Westmore, 2014 paper is reexamined for the role of two fiscal policy instruments, Tax Incentiv

Klimatsmart betongbyggande

Ett av Sveriges hållbarhetsmål är att senast 2045 inte generera några nettoutsläpp av växthusgaser. För att uppnå detta mål krävs kraftiga åtgärder inom alla sektorer. En av dessa är bygg- och fastighetssektorn som 2018 stod för ca 22 % av Sveriges territoriella utsläpp av växthusgaser. Enbart cementindustrin står för ca 5–7 %. Cirka hälften av klimatpåverkan från moderna flerbostadshus uppkommer One of the main sustainability goals in Sweden is to reduce the nations greenhouse gas emissions to a net-zero level by 2045. This is a national implementation of the Paris- Agreement. To achieve this goal measures need to be taken in all industrial sectors. The construction and real-estate sectors are responsible for about 22 % of Sweden’s yearly territorial greenhouse gas emissions. The cement i

Comparison of Methods for Measuring Powder Flowability

Pulver används inom många moment i läkemedelsbranschen, däribland tillverkning av tabletter och dylika processer. Att förstå och kunna anpassa sig till hur pulver beter sig, “flyter”, genom till exempel en tabletteringsmaskin leder till ökad kontroll över tabletternas innehåll och minskad variation mellan individuella tabletter. Vi kallar denna egenskap hos pulvers för deras “flytbarhet”. I vardagPowders are widely used in pharmaceutical applications and understanding their nature is an important aspect of making successful formulations. Powder flowability describes the behaviour of powders and can be measured using several different methods. This study looks at the techniques: angle of repose and tapped density, comparing them to each other and looking at how consistent they are with chan