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β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycans (GAG) that transfers the first galactose unit to xylose in the linker region. Searching for new inhibitors of the GAG biosynthesis, we used saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy to evaluate the binding interactions between β4GalT7 and several pentosides in
While pregnancy clearly reduces the risk for Alcohol Use Disorder (AUD) onset, we know less about the impact on AUD risk of having young children and how these effects vary across maternal age and level of maternal AUD genetic risk. Therefore, in 1.2 million parous Swedish women born 1960-1995, we examined those with a first registration for AUD between ages 15-40 while first pregnant, or while ra
BACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on dise
Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance
BACKGROUND: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively impaired individuals in specialized care settings. The overarching goal is to inform the development of a clinical practice guideline, led by the Alzheimer's Association, for use in clinical practice. METH
Förlossningen är en omvälvande och minnesvärd livshändelse. Den nyblivna mammans fokus ligger på det nyfödda barnet, likaså vårdpersonalens. En förlossning kan leda till allvarliga skador på bäckenbotten (pelvic floor, PF), ibland med komplikationer som inkontinens. Tyvärr förbises eller tonas dessa skador ofta ned – både av nyblivna mödrar och vårdgivare. I Sverige drabbas ungefär 1–4% av kvinnorGiving birth is a profound life event. Most of the time, mothers move their attention to their newborn, as do healthcare providers. Childbirth can cause severe pelvic floor (PF) injuries, potentially leading to complications, such as incontinence. Despite their impact, these injuries are often deprioritised or normalised—both by postpartum women and healthcare providers. In Sweden, 1–4% of women w
We study the role of self-promotion and career advice in sustaining gender differences in labor market outcomes. We conduct an online experiment in which “advisers” advise “workers” to choose between a more ambitious and a less ambitious task based on the worker’s subjective self-assessment. We find that women have lower self-assessments and receive less ambitious career advice as a result. We als
To examine whether processing of negated meanings is facilitated in highly predictable contexts and proceeds incrementally rather than with a delay, we asked participants to read highly constraining sentences containing negated adjectives (e.g., awake/responding/commercial) that were either strongly expected in a high-cloze condition (awake), weakly expected in a low-cloze condition (responding),
Vi har sedan 2009 ordnat seminarier som ger klara och handfasta besked på centrala fastighetsrättsliga ämnen. Denna gång är ämnet Grannelagsrätt. Rättsförhållanden mellan grannar i 3 kap jordabalken utgör grunden för grannelagsrätten, men grannelagsrättsliga frågor regleras även i miljöbalken och plan- och bygglagen.
BACKGROUND: The cross-sectional association between cerebral tissue oxygen saturation (SctO 2) and heart failure (HF) has been previously studied, but the prognostic significance of SctO 2 in HF remains uncertain. This study aimed to assess the role of SctO 2 as a risk factor for all-cause mortality and rehospitalisation, as well as to explore the cross-sectional association between physical ac
Abstract in Serbian:авне библиотеке све више се препознају не само као местаза приступ књигама и информацијама, већ и као битне друштвене ин-фраструктуре у којима је брига саставни део рада библиотекара. Ипак, начини на које библиотекари практикују бригу остају недовољно истра-жени и недефинисани. Стога овај рад, кроз теоријску призму друштвеног инфраструктурног деловања (друштвеног инфраструктури
Structural optimization aims to find the geometry of the best performing design in a predefined setting, using mathematical techniques. The motivation for this study can be categorized into three main benefits: efficient material usage, enhancing existing designs and enabling new technologies. All of these benefits are crucial for solving contemporary technological and environmental challenges. An
How can a live opera performance stimulate visitor involvement by displaying immersive features!? With the AI-based chamber opera The Prophecies, we took the opportunity to structure a visitor’s journey through a series of differentiated chambers inhabited by both human and machine agents. This model was primarily informed bydistinctions made about game immersion from cognitive science and game st
