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High-throughput muscle fiber typing from RNA sequencing data

Background: Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledge has been gathered using labor-intensive and costly methodology that limited these studies. Here, we present a method based on muscle tissue RNA sequencing data (totRNAseq) to estimate the distribution of skeletal muscle fiber types from frozen human samples, allow

Pilotförsök för generell övervakning av pollinatörer – resultat för fältsäsongen 2021

Lunds universitet har på uppdrag av Naturvårdsverket under 2021 utvärderat metodik för nationell pollinatörsövervakning. Metodiken bygger på rapporten ”Proposal for an EU pollinator monitoring scheme” som tagits fram av en expertgrupp inom EU (Potts m. fl. 2020) och ska kunna ge underlag för uppföljning av pollinatörer på nationell nivå med ett främsta fokus på landskapet utanför områden som omfat

Double Isothermal Amplification and CRISPR-Cas12a for Sensitive Detection of Citrinin

An analytical method is developed for ultrasensitive detection of citrinin using double isothermal amplification and CRISPR-Cas12a. Gold nanoparticles (AuNPs) modified with antigen and thiol-terminated, single-strand DNA (ssDNA) are used as a probe. The antigen-modified AuNPs compete with citrinin to bind to magnetic beads coated with an anticitrinin antibody. After a simple magnetic separation, t

Photoinduced Polaron Formation in a Polymerized Electron-Acceptor Semiconductor

Polymerized small molecular acceptor (PSMA) based all-polymer solar cells (all-PSC) have achieved power conversion efficiencies (PCE) over 16%, and the PSMA is considered to hold great promise for further improving the performance of all-PSC. Yet, in comparison with that of the polymer donor, the photophysics of a polymerized acceptor remains poorly understood. Herein, the excited state dynamics i

Knowledge, attitude and practice of physical activity among patients with diabetes in Kilimanjaro region, Northern Tanzania : A descriptive cross-sectional study

Introduction Diabetes mellitus is one of the most common non-communicable diseases and is the fifth leading cause of death in most developing countries. Regular physical activity (PA) is strongly recommended for individuals with diabetes for its beneficial effects in improving blood glucose control and insulin sensitivity, prevention and reduction of morbidities and complications, and its cardiova

Predictors of singleton preterm birth using multinomial regression models accounting for missing data : A birth registry-based cohort study in northern Tanzania

Background Preterm birth is a significant contributor of under-five and newborn deaths globally. Recent estimates indicated that, Tanzania ranks the tenth country with the highest preterm birth rates in the world, and shares 2.2% of the global proportion of all preterm births. Previous studies applied binary regression models to determine predictors of preterm birth by collapsing gestational age a

Feasibility and acceptability of human papillomavirus self-sampling in a semi-urban area in northern Tanzania

Objective: To assess the feasibility and acceptability of HPV self-sampling in Arusha region, northern Tanzania, because the ability for women to self-collect HPV samples can help reduce the number of health facility visits and improve cervical cancer screening coverage rates. Methods: We conducted a facility- and community-based cross-sectional study among 350 women aged 25–55 years in Arumeru di

Prevalence and factors associated with timely initiation of breastfeeding in Kilimanjaro region, northern Tanzania : A cross-sectional study

Background: The World Health Organization (WHO) recommends early initiation of breastfeeding within 1 h as it confers many benefits to the child and prevents neonatal mortality. This study aimed to determine the prevalence and factors associated with timely initiation of breastfeeding in the Kilimanjaro region, northern Tanzania. Methods: We analyzed secondary data for 866 participants from a popu

Health care utilization among individuals who die by suicide as compared to the general population : a population-based register study in Sweden

BACKGROUND: Globally, 700 000 people die every year by suicide. Health care consultation patterns the period before suicide could be one potential way to identify people at risk for suicide. Therefore, this study examines health care patterns up to one year prior to the suicide by age, sex and prior diagnoses and specifically investigates if and how this differs from the general population of Skån

Patterns of Communication About Serious Illness in the Years, Months, and Days before Death

Background: Communication with patients and families about serious illness impacts quality of life and helps facilitate decision-making.Objective: To elucidate the pattern of communication about serious illness for patients who have died in an inpatient setting.Design: Three hundred patients from the Swedish Registry of Palliative Care 2015-2017 were randomly selected for manual chart review.Setti

Applicability of polygenic risk scores in endometriosis clinical presentation

Background: Risk prediction is an essential part of preventative medicine and in recent years genomic information has become an interesting factor in risk models. Polygenic risk scores (PRS) combine the effect of many genetic variations into a single score which has been shown to have predictive value for many diseases. This study aimed to investigate the association between PRS for endometriosis

Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation

Glyphosate-based herbicides (GBH) are among the most sold pesticides in the world. There are several formulations based on the active ingredient glyphosate (GLY) used along with other chemicals to improve the absorption and penetration in plants. The final composition of commercial GBH may modify GLY toxicological profile, potentially enhancing its neurotoxic properties. The developing nervous sys

A real eye-opener : Nursing home staff experiences of co-designing nursing home services together with residents

Introduction: Research and healthcare services struggle to fulfil the desires and needs of nursing home residents, and there is a call for person-centredness in both research and healthcare practice. Involvement of people outside academia in research has been advocated in an effort to increase the relevance and impact of research findings for the public. However, little is known on how to involve

The contralateral hip in slipped capital femoral epiphysis : Is there an easy-to-use algorithm to support a decision for prophylactic fixation?

Purpose: To identify a specific factor that can support the decision for prophylactic fixation in unilateral slipped capital femoral epiphysis. Methods: This retrospective cohort study included a total national population of 379 children diagnosed with slipped capital femoral epiphysis from 2007 to 2013. Regression analysis used information on slip severity, clinical classification of the index hi

Time Trends for Incidence and Net Survival of Cervical Cancer in Sweden 1960-2014 - A Nationwide Population-Based Study

Background: The aim was to investigate time trends for incidence and long-term net survival in the morphologic subtypes and stages of cervical cancer in Sweden during the period 1960 to 2014. Methods: Women with invasive cervical cancer were identified through the Swedish Cancer Registry. Incidence and net survival were calculated according to morphology, age at diagnosis, and FIGO stage at diagno

Nuclear spectra from low-energy interactions

A method to describe spectra starting from nuclear density functionals is explored. The idea is based on postulating an effective Hamiltonian that reproduces the stiffness associated with collective modes. The method defines a simple form of such an effective Hamiltonian and a mapping to go from a density functional to the corresponding Hamiltonian. In order to test the method, the Hamiltonian is

Serving the community while balancing multiple responsibilities – experiences of working as a paid part-time firefighter

Purpose: The purpose of this study was to describe experiences of working as a paid part-time firefighter (PTF) in Swedish rural areas. Design/methodology/approach: An inductive explorative design was used, based on interviews with 18 paid PTFs in Sweden. Data were analyzed using qualitative latent content analysis. Findings: Three themes emerged from the interviews and describe paid PTFs’ experie