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Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronar

Mobile Stroke Units (MSUs) are specialized ambulances that can diagnose and treat stroke patients; hence, reducing the time to treatment for stroke patients. Optimal placement of MSUs in a geographic region enables to maximize access to treatment for stroke patients. We contribute a mathematical model to optimally place MSUs in a geographic region. The objective function of the model takes the tra

The Sweden Democrats is a nationalist right-wing populist party with roots in neo-Nazism and white supremacist beliefs. The party has experienced continuous progress during the last decade in Sweden, attracting 20.5 per cent of the vote in the general election of 2022. A combination of discourse analytical methods is applied to study the comment sections of the party's official social media accoun

This paper seeks to reconstruct the worldview informing Iberian overseas expansion during the long sixteenth century, arguing that this worldview was more indebted to Renaissance cosmology than to a recognisably modern scientific worldview. The paper describes how this cosmology provided the intellectual resources necessary to justify overseas expansion to those who doubted its viability and legit

The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) was to provide evidence-based clinical guidance about the use of higher versus lower oxygenation targets for adult patients in the intensive care unit (ICU). The guideline panel comprised 27 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. We adhered to the met

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian rand

Feathers comprise a series of evolutionary innovations but also harbour colour, a key biological trait known to co-vary with life history or complex traits. Those relationships are particularly true in melanin-based pigmentation species due to known pleiotropic effects of the melanocortin pathway – originating from melanin-associated phenotypes. Here, we explore the molecular basis of melanin colo

This study examines trait-level sense of self in 32 participants with varying meditation experience, with a special focus on the sense of self-boundaries and the sense of being a subject of experience, what is here referred to as perspectival ownership of experience. Results from qualitative and quantitative analyses of in-depth phenomenological interviews suggested a quadratic relation between se

Purpose: Starting from a power perspective, the study problematizes the prevailing normative and management-dominated view of self-initiated employee ambassadorship on social media. The aim is to provide a more nuanced and critical understanding of the negative aspects of this phenomenon.Design/methodology/approach: The empirical material encompasses qualitative interviews with employees from 14 o

Furfural is an intermediary toxic aldehyde compound produced during heat-induced food processing and storage. Furfural is also formed by the degradation of cellulosic insulation in oil-immersed electric potential transformers, whose level is an important indicator of aging for replacement. In this study, we report a new means to detect the trace level of furfural in a colorimetric manner. Furfural

Introduction: Whether and under what conditions scientific knowledge provided by experts actually leads to political action is a question that academic research in various fields have focused on at length, without reaching a definitive answer. The position of expertise is especially delicate within the global environmental governance sphere containing multiple values, worldviews and epistemologica

Introduction: Dementia is a condition (a collection of related signs and symptoms) that causes a continuing deterioration in cognitive function, and millions of people are impacted by dementia every year as the world population continues to rise. Conventional approaches for determining dementia rely primarily on clinical examinations, analyzing medical records, and administering cognitive and neur

Vid förbränning av avfall produceras stora mängder slaggrus som både är ett avfall, som kräver hantering, och en resurs, genom dess goda materialegenskaper. Slaggrus definieras i denna studie som sorterad bottenaska från avfallsförbränning. En potentiell spridningsväg för föroreningar från slaggruset vid anläggningsarbete är damning. Damning är en miljöoch hälsofara även utan föroreningar i materi

Because of varied topography and landscape heterogeneity，Tianshan Mountain has extremely complex hydrological processes. Considering that the climate change poses a great threat to the water security，it’s necessary to simulate the change of water elements quantitatively and systematically along with elevation. In this study，we applied the modified FLEXG-Δh model to four classic river basins in Tia

Slowed adaptation of the QT interval to sudden abrupt heart rate (HR) changes has been identified as a marker of ventricular arrhythmic risk. However, abrupt HR changes are difficult to induce in patients. Quantifying the QT adaptation time in gradual HR changes, as observed in ECGs recording during an exercise stress test, has been recently proposed. The time lag between the QT series and an inst

Driftmetoder mot höga partikelhalter orsakade av vägdamm i gatu- och vägmiljöer har under lång tid utvärderats i vanlig gatumiljö. Resultaten är dock ofta förhållandevis svårtolkade på grund av inverkan av meteorologi och omfattande inblandning från andra partikelkällor än just den gata som studeras. För att komma vidare med mer detaljerade studier av metodik och strategi och för att få mer lättol

High Capacity vehicles (HCV) have dimensions outside general access rules. The High Capacity Transport (HCT) concept consists of roads, vehicles, operations, and regulations. The Intelligent Access (IA) framework gives access to roads only if compliance assurance schemes are used to ensure “the right vehicle is on the right road at the right time with the right axel loads and driven at the right s