The transcription factor ZNF224 plays a key proapoptotic role in chronic myelogenous leukemia (CML), by modulating Wilms Tumor protein 1 (WT1) dependent apoptotic genes transcription. Recently, we demonstrated that Bcr-Abl signaling represses ZNF224 expression in Bcr-Abl positive CML cell lines and in CML patients. Interestingly, Imatinib and second-generation tyrosine kinase inhibitors specifical

Thermal uniformity in the flow field plate of proton exchange membrane fuel cells (PEMFCs) is crucial for their power generating efficiency and reliability and therefore, has attracted much attention. The present numerical study is an attempt to optimize the flow channels via replacement of convectional zigzag continuous channels by tree-like bifurcated channels radially outwards. The numerical mo

Visceral leishmaniasis (VL) is a vector-borne disease, highly influenced by environmental factors, which is an increasing public health problem in Iran, especially in the north-western part of the country. A geographical information system was used to extract data and map environmental variables for all villages in the districts of Kalaybar and Ahar in the province of East Azerbaijan. An attempt t

Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatogr

MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA (sRNA) libraries, with matching Cap Analysis Gene Expression (CAGE) data, from 396 human and 47 mouse RNA samples.

Inclusive isolated-photon production in pp collisions at a centre-of-mass energy of 13 TeV is studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of 3.2 fb−1. The cross section is measured as a function of the photon transverse energy above 125 GeV in different regions of photon pseudorapidity. Next-to-leading-order perturbative QCD and Monte Carlo event-gener

This study evaluates the impact of achieving tertiary eligibility in upper-secondary education on tertiary education and earnings in Sweden. Using a regression discontinuity design, we estimate the impact of tertiary eligibility and show that it has a substantial impact on the probability of enrolling in tertiary education. For students who achieve tertiary eligibility, the probability of enrollin

This study considers evolutionary models with non-uniformly random matching when interaction occurs in groups of n>=2 individuals. In such models, groups with different compositions of individuals generally co-exist and the reproductive success (fitness) of a specific strategy – and consequently long-run behavior in the population – varies with the frequencies of different group types. These frequ

Parkinson's Disease (PD) is a complex and heterogeneous neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta and pathological intracellular accumulation of alpha-synuclein (α-syn). In the vast majority of PD patients, the disease has a complex etiology, defined by multiple genetic and environmental risk factors. Common genetic

IHE has published a new comparator report on the cost of cancer and access to cancer medicines. The report is a condensed version of the previously published report, Comparator report on patient access to cancer medicines in Europe revisited (IHE Report 2016:4) and focusing on the UK.The report reveals similar trends in the UK as in the rest of Europe: incidence of cancer is increasing, as is mort

Affinal avoidance registers are strategies of restrained linguistic conduct in relation to one’s in-laws. Current theories are primarily concerned with two types of strategies: (1) taboos on uttering the proper names of affines, and (2) substitution of everyday words with dedicated parallel lexicon in the presence of affines (so-called “mother-in-law languages”). However, the role of pronouns has

STUDY QUESTION Does an intensive weight reduction programme prior to IVF increase live birth rates for infertile obese women? SUMMARY ANSWER An intensive weight reduction programme resulted in a large weight loss but did not substantially affect live birth rates in obese women scheduled for IVF. WHAT IS ALREADY KNOWN Among obese women, fertility and obstetric outcomes are influenced negatively wit