Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect associations. As prevalence rates in IS are markedly affected by age, and younger onset cases may have h

Most biological functions of carotenoids relate to strong visible absorption. In a quest to protein matrix effects on spectra, the shifts produced by solvent refractive index (n) and static dielectric permittivity (ε) were quantified for visible absorption maxima of β-carotene and a model compound with sharper bands, tetra-tert-butylnonaene ttbP9. The dispersive red shift that depends on optical d

Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. Methods: 4,666 controls were pooled

Research on episodic memory has established that spontaneous eye movements occur to spaces associated with retrieved information even if those spaces are blank at the time of retrieval. Although it has been claimed that such looks to "nothing" can function as facilitatory retrieval cues, there is currently no conclusive evidence for such an effect. In the present study, we addressed this fundament

The content of zinc, iron, calcium and phytate in the 16 most consumed foods from 5 villages in a tropical rural area of Bolivia was analyzed. The fooditems were selected according to a completed food frequency questionnaire. Minerals were analyzed by atomic absorption and phytates by HPIC chromatography. The molar ratios of phytate:mineral are presented as indication of the mineral bioavailabilit

Cultural transmission can increase the flexibility of behavior, such as bird song. Nevertheless, this flexibility often appears to be constrained, sometimes by preferences for learning certain traits over others, a phenomenon known as "biased" learning or transmission [1]. The sequential colonization of the Atlantic Islands by the chaffinch (Fringilla coelebs) [2] provides a unique model system in

The Gauss–Lagrange model for ocean waves describes the vertical and horizontal movements of water particles as three correlated Gaussian fields. The model can produce irregular waves, asymmetric in both vertical and horizontal direction, and by judicious choice of a single skewness parameter the front–back asymmetry can be regulated to realistic values. In this paper, it is shown that this additiv

Ideals and visions of a Library 2.0 have in recent years been widely discussed in public library research and practice. Influenced by the Web 2.0 discourse, the Library 2.0 rhetoric has to a large extent been coloured by utopian and revolutionary overtones, identifying social media as key to transforming the public library institution. While previous research has primarily addressed this developme

The transient receptor potential, vanilloid 4 (TRPV4), is a calcium permeable ion channel expressed in airway epithelial cells. Based on studies of cell lines and animals, TRPV4 has been suggested to play a role in the regulation of ciliary beat frequency (CBF). Whether the same is true for human ciliated epithelial cells is not known. Therefore, the aim was to examine the expression and function

Hyperthermia is a frequent complication in patients with acute ischemic stroke. On the other hand, therapeutically induced hypothermia has shown promising potential in animal models of focal cerebral ischemia. This Guideline Document presents the European Stroke Organisation guidelines for the management of temperature in patients with acute ischemic stroke.

The aim of this article is to contribute to literature with new findings from biogenetics that are becoming increasingly important. In particular, we will discuss the new analytic frameworks that may open as a result of the incorporation of epigenetics in evolutionary economic thinking. This new approach is illustrated by studying the evolution of big Internet industry groups such as Apple, Google

BACKGROUND: It is controversial whether breast reconstruction with a microvascular free flap should be done without restrictions in patients who have not had radiotherapy. Many regard it as too expensive, but some consider it better and more economically advantageous than an implant reconstruction. METHODS: Databases of publications were searched to find out under what conditions is it suitable to

Objectives: Evidence regarding the efficacy and effectiveness of certolizumab pegol (CZP) in rheumatoid arthritis (RA) patients who have failed to respond to treatment with a tumour necrosis factor inhibitor (TNFi) is limited. The aim of this study was to describe the effectiveness and survival-on-drug of CZP in a real-life setting, both in TNFi-naive patients and in patients who had previously fa

Vision is an important source of information for many animals. The crystalline lens plays a central role in the visual pathway and hence the ecology of fishes. In this study, we tested whether the different light regimes in the Mediterranean and Red Seas have an effect on the optical properties of the lenses in the rivulated rabbitfish, Siganus rivulatus. This species has migrated through the Suez

Scandinavia is considered a region with a low prevalence of antimicrobial resistance. However, the number dof multidrug-resistant (MDR) Gram-negative bacteria is increasing, including metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa. In this study MBL-producing P. aeruginosa isolates identified in Norway (n = 4) and Sweden (n = 9) from 1999 to 2007 were characterized. Two internationa

One of the major concerns regarding climate change in high latitudes is the potential feedback from greenhouse gases (GHG) being released from thawing peat soils. In this paper we show how vegetational patterns and associated GHG fluxes in subarctic palsa (peat mounds with a permanently frozen core) mires can be linked to climate, based on field observations from fifteen palsa sites distributed in

Abstract in Undetermined This study employed microCT to investigate whether image resolution affects bone structural parameters differently in healthy normal and osteoporotic trabecular bone. With increasing image voxel size, the originally detected differences between sample groups diminished. The results suggest that structural differences may not be reliably detected with clinical scanners.

Seven novel tertiary alcohol containing linear HIV-1 protease inhibitors (PIs), decorated at the para position of the benzyl group in the P1' side with (hetero)aromatic moieties, were synthesized and biologically evaluated. To study the inhibition and antiviral activity effect of P1-P3 macro-cyclization, 14- and 15-membered macrocyclic Pis were prepared by ring-closing metathesis of the correspond

Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/