This chapter introduces a new framework for thinking about climate justice. Climate change and climate negotiations actualize equity considerations in at least three relevant dimensions: distributions of benefits and burdens across countries, within countries, and across individuals in the world. Our proposed framework enables researchers and policymakers to visualize and combine different equity

This paper introduces a work-in-progress devoted to analysing the architectural design, public-performative functionality, and cultural-political semiotics of the Safra Square (ספרא כיכר, Kikar Safra) and City Hall complex, Western Jerusalem. Built around the historic Town Hall of the British Governate, and inaugurated in 1993, the City Hall complex is strategically located along the bustling pede

Recent years have seen the emergence of critical studies pro-duced by third- generation Displaced Persons (hereafter DPs),questioning ethno-nationalist historical narrations, hegemonicin the community. Yet, in the Ukrainian diaspora in Canada, suchstudies have been absent. Kassandra Luciuk’s current study iswritten by someone raised in the political elite of the Ukrainianethno-nationalist communit

Background Compression neuropathy, such as carpal tunnel syndrome (CTS), results in changed afferent nerve signaling, which may result in changes in somatosensory brain areas. The purpose of this study was to assess cerebral changes following unilateral CTS and to assess short-term and long-term cerebral effects of guided plasticity treatment using ipsilateral cutaneous forearm deafferentation. Me

Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by cytogenetic abnormalities, such as t(11;14)(q13;q32), resulting in CCND1 overexpression. The rs9344 G allele within CCND1 is the most significant susceptibility allele for t(11;14). Sequencing data from 2 independent cohorts, CoMMpass (n = 698) and Mayo Clinic (n = 661), confirm the positive association between the G allele an

ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific amino acid residues on substrate proteins or to ADP-ribose itself. Currently, 22 human genes encoding proteins that possess an ADP-ribosyltransferase catalytic domain are known. Recent structural and enzymological evidence

Cyclase-associated proteins (CAPs) are evolutionary conserved G-actin-binding proteins that regulate microfilament turnover. CAPs have a modular structure consisting of an N-terminal adenylate cyclase binding domain, a central proline-rich segment, and a C-terminal actin binding domain. Protozoan parasites of the phylum Apicomplexa, such as Cryptosporidium and the malaria parasite Plasmodium, expr

The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-3. PARP-3 is not activated upon binding to DNA and is a mono-ADP-ribosylase, in contrast to PARP-1 a

I södra Sverige kan du hitta byn Immeln, som ligger vid södra änden av sjön Immeln. Det är en liten by med cirka 300 invånare. Antalet invånare ökar dramatiskt under sommarmånaderna på grund av den vackra naturen och utomhusaktiviteterna som miljön erbjuder. Detta examensarbete utforskar en industribyggnad och dess tomt som tar upp en stor del av den östra strandkanten av denna by. Genom att utforIn the southern part of Sweden you can find the small village called Immeln, located at the south end of lake Immeln. It’s a small village with around 300 residents, which increases dramatically during the summer months because of its beautiful nature and outdoor activities. This thesis project explores an industrial building and its plot that is taking up a large part of the eastern shoreline of

The thesis investigates how a brownfield development, a harbour, can be developed, how urban agriculture, both commercial food production and recreational cultivation, can be integrated into the design and how it should be designed to be both effective and enjoyable and inviting for visitors. A design proposal has been produced that shows such a development. The design proposal is supplemented wit

Poly-ADP-ribose polymerases (PARPs) catalyze transfer of ADP-ribose from NAD(+) to specific residues in their substrate proteins or to growing ADP-ribose chains. PARP activity is involved in processes such as chromatin remodeling, transcription control, and DNA repair. Inhibitors of PARP activity may be useful in cancer therapy. PARP2 is the family member that is most similar to PARP1, and the two

The 70-kDa heat shock proteins (Hsp70) are chaperones with central roles in processes that involve polypeptide remodeling events. Hsp70 proteins consist of two major functional domains: an N-terminal nucleotide binding domain (NBD) with ATPase activity, and a C-terminal substrate binding domain (SBD). We present the first crystal structures of four human Hsp70 isoforms, those of the NBDs of HSPA1L

Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is the presence of very short subpellicular actin filaments. Therefore, F-actin stabilizing proteins likely play a central ro

Paraplegin is an m-AAA protease of the mitochondrial inner membrane that is linked to hereditary spastic paraplegias. The gene encodes an FtsH-homology protease domain in tandem with an AAA+ homology ATPase domain. The protein is believed to form a hexamer that uses ATPase-driven conformational changes in its AAA-domain to deliver substrate peptides to its protease domain. We present the crystal s

Importance: Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking. Objective: To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (< 32 weeks) neonates. Data sources: A search of M

Lake level, area and volume are sensitive indicators of climate change. At present, many studies have focused on the interannual water balance of lakes, but lake level and area can change remarkably with seasons, especially for lakes with seasonal ice cover. Zhari Namco, a seasonal frozen lake, was selected as an example to investigate its seasonal water balance. Multi-source altimetry and Landsat

Purpose: Fluorescence in situ hybridization (FISH) is the current gold standard assay that provides information related to risk stratification and therapeutic selection for individuals with plasma cell neoplasms. The differential hybridization of FISH probe sets in association with individuals’ genetic ancestry has not been previously reported. Methods: This retrospective study included 1224 bone