The Role of Membrane Trafficking in G Protein-Coupled Receptor Regulation
Movements of a receptor in the plasma membrane and within the cell influence receptor function and physiology. I have investigated the role of such movements, generally known as membrane trafficking, in G protein-coupled receptor regulation. My studies show that agonist-promoted internalization and postendocytic sorting determine the degree of resensitization of opioid m (MOR) and d (DOR) receptor