BACKGROUND: Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise in preclinical studies and case reports. We hypothesized that blockade of IL1RAP (IL-1 receptor accessory protein), a shared subunit of the IL-1, IL-33, and IL-36 receptors, could be more efficient than IL-1 blockade alone. METHODS: We induced coxsackie

Biopharmaceuticals, of which monoclonal antibodies are a mainstay, have revolutionized healthcare by enabling treatments with high precision and efficacy. However, their established manufacturing processes, particularly the downstream process, are complex, resource-intensive, and expensive, limiting global access to these drugs. This thesis examines how a more efficient, sustainable, and thus less

OBJECTIVE: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common f

OBJECTIVES: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.METHODS: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were avail

Telomere length (TL) is a biomarker linked to age-related diseases based on its sensitivity to oxidative DNA damage and inflammation. Methylmercury (MeHg) is a common pollutant in fish. It may induce oxidative stress leading to shorter TL. However, previous research showed contradictory results and dose-concentration dependencies and non-linear relationships have been suggested. This study was car

Public sector organizations increasingly use digital platforms to foster value co-creation among diverse stakeholders and to address complex societal challenges, such as those related to sustainable development. Different kinds of digital platforms have been recognized as potential drivers of the societal transition toward a circular economy. However, little is known about the organization, govern

Background: It is thought that patients with inborn errors of immunity (IEI) are more susceptible to severe coronavirus disease 2019 (COVID-19) than the general population, but a quantification of this potential risk is largely missing. Objective: We assessed the impact of COVID-19 on patients with IEI. Methods: A nationwide cohort study was performed to estimate the relative risk (RR) for hospita

The clarinetist, composer, and conductor Jörg Widmann is one of the shining lights of contemporary music. His credo is to combine tradition with new developments, resulting in timbres whose virtuosity, intensity, and directness both surprise and oftentimes confront the listeners, but also challenge them with quiet, fragile moments. The transparent, ethereal orchestral piece Armonica seems to defy

Real Filharmonía de Galicia participated in the Hércules Brass Festival in Celanova under the direction of Sebastian Zinca, with Hakan Hardenberger as soloist.Pieces included:Johann Georg Albrechtsberger: Concertino für Trompete, Streicher undB.c. in Es-DurM. v. Martinez: Sinfonía en Do M: 2.2.0.0 - 2.2Joseph Haydn: Konzert für Trompete und Orchester Es-Dur Hob. VIIe:1 Edvard Grieg: Zwei elegische

Self-injury is associated with significant psychological distress and functional impairments, including difficulties with self-care. However, little is known about how individuals engaging in self-injury perceive and manage self-care in their daily lives. This study aimed to explore the lived experiences of self-care among individuals receiving psychiatric treatment for self-injury and to identify

Despite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: PapDespite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: Pap

Caloplaca ruderum is reported as new to Sweden from three localities. Based on a phylogenetic analysis it is transferred to the genus Flavoplaca, where the closest relatives are F. communis, F. maritima and F. havaasii. In addition, Caloplaca sol and C. itiana are transferred to Flavoplaca. The identities of C. itiana, C. calcitrapa, and C. dalmatica in the sense of British treatments are discusse

This article explores the development of international adoption policy in post-liberation South Korea, emphasizing the roles of American and Korean professional social workers. By analyzing the orphan registry and a pivotal international adoption law, it reveals how international adoption in South Korea presents a unique opportunity to observe the formation of modern social policy in a newly liber

This article examines the early development of South Korean intercountry adoption to Sweden. It focuses particularly on two disruptions in the movement of children between the two nations, drawing on archival sources in Sweden, South Korea, and Denmark. The article demonstrates that South Korean–Swedish adoption was deeply bound up in the shifting Cold War relations within and between the Korean p

Contrary to the dominant perception of transnational adoption as an act of goodness, an increasing number of Korean adult adoptees in Denmark have raised critical voices about the political economy of transnational adoption since the mid-2000s. They have participated in the adoption debate not just as individuals, but through collective critiques and mobilisation. This article looks at the develop

The COVID-19 pandemic put a lot of strain on healthcare organizations. Nurses accountfor over 50% of healthcare staff, and how nurses perform in their work is influenced by a number ofhuman and work environmental factors. However, to our knowledge, there has not been a previousstudy with the intention to look at all areas that affect a sustainable working life and how theseimpact nurses’ mental we