Temperature-dependent conformational change of two de novo proteins : Expression, purification and characterisation of two de novo proteins predicted to undergo conformational change at elevated temperatures
Conformational changes are essential for the function of many proteins and is determined by the sequence of amino acids and interactions between them. With computational protein design, new de novo proteins with the ability to undergo conformational changes have been designed. Also, proteins that are one amino acid apart and predicted to have two different conformational states, with the ability t