BACKGROUND: Leukotriene B4 (LTB4) recruits and activates neutrophils. Accordingly, this leukotriene is involved in innate defense actions. OBJECTIVE: To examine if nasal LTB4 can produce neutrophil activity and to explore whether or not LTB4 can condition neutrophils to exert virucidal effects in vitro and in vivo. METHODS: 1. Twenty-three healthy subjects received nasal LTB4 in a randomized and s

Ten rhenium carbonyl complexes-[Re(H)(CO)(3)(1a)], [Re-3(mu-H)(3)(CO)(10) (1a)], [Re-2(CO)(9)(2a)], [Re-2(CO)(8)(2a)], [Re-2(CO)(9)(2b)], [{Re-2(CO)(9)}(2)(2b)], [Re-2 (CO)(8)(2b)], [Re-2(CO)(8)(1b)], [Re-2(mu-H)(2)(CO)(6)(2b)] and [Re-3(mu-H)(3)(CO)(11)(2b)]-containing different bidentate chiral phosphine ligands of the Josiphos (1a, 1b) and Walphos (2a, 2b) families have been synthesized and ful

Carbonyl compounds formed in sea buckthorn berry (Hippophae rhamnoides) and oil samples as a result of lipid oxidation were determined by enzymatic hydrolysis followed by derivatisation with 2,4-dinitrophenylhydrazine and analysed by LC-UV and electrospray ionisation (ESI) tandem mass spectrometry (MS/MS). Several classes of carbonyl compounds such as saturated, unsaturated, linear and branched al

Background: Acetyl Coenzyme A carboxylase beta (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine wheth

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. Aims. We aim to determine C, N, and O abundances in stars of Galactic open clusters of the Gaia-ESO survey and to compare the observed abundances with those predicted by current stellar and Galactic evolution models.

Current trends in industrial automation are the need for customizable production, vertical integration, more advanced sensors and actuators, and shorter time to market. The currently used control systems and languages for control were developed with a more static production in mind. More flexible languages and tools are needed to get a more flexible production. The flexible graphical programming l

Impregnation behaviors of reverse-phase silica materials and C18-silica HPLC columns were studied using di-(2-ethylhexyl)phosphoric acid (HDEHP) as a model extractant. Initially, the adsorption efficiency of the ligand on different types of bulk particles was investigated using various concentration of HDEHP in different composition of methanol/water mixtures based on a batch technique. Subsequent

Soil gas production processes, mainly anaerobic or aerobic soil respiration, drive major gas fluxes across the soil-atmosphere interface. Carbon dioxide (CO2) effluxes, an efflux which in most ecosystems is a result of both autotrophic and heterotrophic respiration, in particular have received international attention. The importance of both CO2 and methane (CH4) fluxes are emphasised in the Arctic

Political institutions are keen to use the best available scientific knowledge in decision-making. For environmental policy, relevant scientific evidence can be complex and extensive, so expert judgment is frequently relied upon, without clear links to the evidence itself. We propose a new transparent process for incorporating research evidence into policy decisions, involving independent synopsis

In this study calorimetric measurements provided evidence of a drastic increase of spinach leaf gross metabolism as a consequence of vacuum impregnation (VI) at a minimum pressure of 150 mbar with trehalose and sucrose isotonic solutions. When applying VI extracellular air is replaced by the impregnation solution, potentially limiting tissue respiration to any remaining air volume in the tissue. H

Intraductal neoplasms of the pancreas are classified as intraductal tubulopapillary neoplasms (ITPNs) and intraductal papillary mucinous neoplasm (IPMNs) in the current WHO classification. ITPN is a rare tumor and there are only a few cases of ITPN reported in the literature. We present the case of an otherwise healthy 42-year-old male, who presented with upper abdominal pain. He was subsequently

How is meaning created by a poem? Through the invisible ideas and thoughts conveyed by the text or through the physical presence of book, paper and print? In Bodies of Poems the author argues that the material properties of poetic texts are meaningful in their own right but often ignored and made invisible in poetry criticism. Through a number of examples ranging from the introduction of print tec

Popular Abstract in Swedish Trots ett sunt leverne med regelbunden motion och nyttig mat kan vi inte alltid förhindra risken att drabbas av vissa typer av cancer som till exempel hjärntumörer. Den vanligaste formen av elakartade hjärntumörer heter glioblastoma multiforme och är också den mest aggressiva. Symptomen varierar beroende på tumörens storlek och var i hjärnan den växer, och patienter kanGlioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with in

Background: Microarray gene-profiling of invasive breast cancer has identified different subtypes including luminal A, luminal B, HER2-overexpressing and basal-like groups. Basal-like invasive breast cancer is associated with a worse prognosis. However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is still unknown. Our aim was to study the prognosis of basal-like DCIS in a large pop